A Research Project Led by Dr. Fabrice Darche Aiming to Improve the Treatment of Sinus Node Dysfunction

The development of a cardiac pacemaker derived from human stem cells would represent a major breakthrough in cardiac health. It could significantly improve the treatment of sinus node dysfunction and enhance the body’s biological acceptance of pacemakers.

Dr. Fabrice Darche, a Luxembourgish cardiologist and researcher based at Universitätsklinikum Heidelberg, is leading a research project focused on improving the treatment of cardiac arrhythmias through the use of human stem cell technologies. The project also aims to provide new fundamental insights into the pathophysiology of sinus node diseases.

The Department of Cardiology, Angiology, and Pulmonology at Heidelberg University Hospital is one of the most renowned cardiovascular centers in Europe. In addition to delivering high-level patient care, the department is recognized for its outstanding translational research. Numerous peer-reviewed publications and strong collaborations with prestigious national and international institutions reflect the department’s scientific excellence.

Discover the article "Improved Generation of Human Induced Pluripotent Stem Cell-Derived Cardiac Pacemaker Cells Using Novel Differentiation Protocols," published on June 30, 2022.

 Read the article "Objectif : Mettre au point un pacemaker biologique !" published on August 2023 by MedInLux magazine.